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The non-linear pharmacokinetics of prednisone and prednisolone

✍ Scribed by James J. Ferry Jr.; John G. Wagner


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
510 KB
Volume
9
Category
Article
ISSN
0142-2782

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The non-linear pharmacokinetics of predn
✍ James J. Ferry Jr.; John G. Wagner πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 448 KB

Three simple linear and three simple non-linear pharmacokinetic models are presented which incorporate the reversible metabolism that occurs between prednisone and prednisolone. Under steady-state conditions it is possible to not only distinguish between the linear and non-linear models but also to

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The protein binding characteristics of prednisone and prednisolone were determined in human and rabbit plasma and in a 4.7 per cent human serum albumin (HSA) solution. The influence of plednisolone on prednisone binding in human plasma was also examined. Prednisolone exhibited nonlinear binding and

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The pharmacokinetics of prednisone and prednisolone was examined in 12 healthy male subjects to assess the bioavailability and the parameters of reversible metabolism between the two steroids. After an oral prednisone dose of 0.8mg kg-' and an intravenous prednisolone dose of 0.66 mg kg-', the bioav