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The non-linear pharmacokinetics of prednisone and prednisolone. I. Theoretical

✍ Scribed by James J. Ferry Jr.; John G. Wagner

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
448 KB
Volume
7
Category
Article
ISSN
0142-2782

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✦ Synopsis

Three simple linear and three simple non-linear pharmacokinetic models are presented which incorporate the reversible metabolism that occurs between prednisone and prednisolone. Under steady-state conditions it is possible to not only distinguish between the linear and non-linear models but also to determine which particular model of each group applies to a given set of data. While the non-linear conversion of prednisolone to prednisone is important in explaining the pharmacokinetics of prednisone in all three non-linear models, the same is not true for prednisolone.

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