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Effect of plasma gangliosides on the growth of ehrlich ascites tumor

✍ Scribed by Sandip Saha; Asit Ghosh

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
522 KB
Volume
46
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Total plasma gangliosides of Ehrlich ascltes tumor‐bearing mice enhanced tumor growth when adoptively transferred with the same tumor cells in mice. However, individual gangliosides acted differently. Out of 6 gangliosides separated from plasma, 2 components enhanced tumor growth, whereas the remaining 4 inhibited tumor growth, Neither of the 2 enhancing components in various combinations with the 4 inhibitory components could restore the enhancing effect. The enhancing effect was restored only when both the enhancing components were mixed with the remaining 4 ganglioside components, i. e., with full/complete reconstitution.

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