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Effect of withaferin a on ehrlich ascites tumor cells — cytological observations

✍ Scribed by Batia Shohat; Simon Gitter; David Lave

Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
718 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Withaferin A, a steroidal lactone with carcinostatic properties, isolated from the leaves of Withania somnifera Dun., produced a mitotic arrest in the metaphase of dividing Ehrlich ascites carcinoma cells. In addition this compound also induced vacuolization of the cytoplasm. A single dose of withaferin A, administered 24 hours after Ehrlich ascites implantation, caused growth reduction followed by disappearance of the tumor in 80% of the mice. These mice were found to be resistant to rechallenge with Ehrlich ascites tumor cells. The inhibition of Ehrlich ascites tumor growth is thought to represent a combined effect of withaferin A action and immune reactions.

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