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EFFECT OF METHOTREXATE ON THE CELL CYCLE OF L1210 LEUKEMIA

โœ Scribed by S. A. GONCHAROVA; O. S. FRANKFURT

Book ID
114715155
Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
381 KB
Volume
9
Category
Article
ISSN
0960-7722

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Methionine-auxotrophic L1210 cells were used to study the effect of methotrexate (MTX) on methionine uptake and metabolism. MTX was shown to inhibit amino acid transport systems and cause a decrease of methionine uptake into L1210 cells. Conversely, a nonmetabolizable amino acid analogue reduced MTX