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Effect of grapefruit juice intake on etoposide bioavailability

✍ Scribed by Reif, Stefanie; Nicolson, Marianne; Bisset, Donald; Reid, Muriel; Kloft, Charlotte; Jaehde, Ulrich; McLeod, Howard


Book ID
113023436
Publisher
Springer
Year
2002
Tongue
English
Weight
200 KB
Volume
58
Category
Article
ISSN
0031-6970

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Previous studies with rats indicate that nifedipine undergoes both hepatic and extrahepatic presystemic metabolism after peroral (po) administration, and that its bioavailability is increased and absorption delayed by concomitant administration of grapefruit juice concentrate (GJC). Hence, the effec