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Effect of etodolac, a selective cyclooxygenase-2 inhibitor on the expression of the E-cadherin-catenin complexes in gastrointestinal cell lines

✍ Scribed by Masao Noda; Takafumi Takama; Tsuguhiro Kimura; Muneta Tomizawa; Shoji Mitsufuji; Hiroyuki Sugihara; Tadashi Kodama; Kei Kashima; Takanori Hattori

Book ID: 119425415
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 185 KB
Volume: 118
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(00)82292-1

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## Abstract ## Background. The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in