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The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines

✍ Scribed by de Souza Filho, J P; Correa, Z M S; Marshall, J C; Anteka, E; Coutinho, A B; Martins, M C; M N Burnier,

Book ID: 110036023
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 94 KB
Volume: 20
Category: Article
ISSN: 0950-222X
DOI: 10.1038/sj.eye.6701938

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## Abstract The overexpression of cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (iNOS) has been previously reported in head and neck squamous cell carcinoma (HNSCC), as well as in many cancers. We hypothesized that endogenous nitric oxide (NO) might increase the expression of COX‐2 i