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Effects of etodolac, a selective cyclooxygenase-2 inhibitor, on the expression of E-cadherin-catenin complexes in gastrointestinal cell lines

✍ Scribed by Masao Noda; Yoichi Tatsumi; Muneta Tomizawa; Takafumi Takama; Shoji Mitsufuji; Hiroyuki Sugihara; Kei Kashima; Takanori Hattori

Publisher
Springer Japan
Year
2002
Tongue
English
Weight
365 KB
Volume
37
Category
Article
ISSN
0944-1174

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## Abstract ## Background. The protooncogenes Ets‐1 and Ets‐2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenase‐2 (COX‐2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Ets‐1 and Ets‐2 synthesis in