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Effect of DNA Local Conformation on the Affinity and Binding Specificity of bis-Netropsins to DNA

โœ Scribed by A. N. Surovaya; S. L. Grokhovsky; G. Burckhardt; H. Fritzsche; Ch. Zimmer; G. V. Gursky


Book ID
110397862
Publisher
SP MAIK Nauka/Interperiodica
Year
2002
Tongue
English
Weight
116 KB
Volume
36
Category
Article
ISSN
0026-8933

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Actinomycin-D (actD) binds to natural DNA at two different classes of binding sites, weak and strong. The affinity for these sites is highly dependent on DNA sequence and solution conditions, and the interaction appears to be purely entropic driven. Although the entropic character of this reaction h