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Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA

โœ Scribed by J. Portugal; M.J. Waring


Book ID
115919789
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
506 KB
Volume
225
Category
Article
ISSN
0014-5793

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Accessibility of the minor groove of DNA
โœ A. F. Melnikova; A. S. Zasedatelev; A. M. Kolchinsky; G. V. Gursky; A. L. Zhuze; ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Springer ๐ŸŒ English โš– 380 KB

The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit