Drug-DNA binding specificity: Binding of netropsin and distamycin to poly(d2NH2A-dT)
β Scribed by Dipak Dasgupta; Frank B. Howard; V. Sasisekharan; H. Todd Miles
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1990
- Tongue
- English
- Weight
- 253 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0006-3525
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The Raman spectra of distamycin and its complex with DNA were examined in both H~2~O and D~2~O solutions. To facilitate band assignments, Raman spectra of several small model compounds of distamycin were also obtained. On binding to DNA, the Cο£ΎO stretching band at 1620 cm^β1^ (amide I b
The structural selectivity of the DNA-binding antitumor drug ditercalinium was investigated by competition dialysis with a series of nineteen different DNA substrates. The 7H-pyridocarbazole dimer was found to bind to double-stranded DNA with a preference for GC-rich species but can in addition form