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Probing the DNA-Binding Affinity and Specificity of Designed Zinc Finger Proteins

โœ Scribed by Jantz, Derek; Berg, Jeremy M.


Book ID
119206050
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
827 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract A peptide corresponding to the three zinc finger domains of the human transcription factor Sp1 has been expressed and found to bind a consensus Sp1 binding site with the sequence 5โ€ฒโ€GGGGCGGGGโ€3โ€ฒ. Examination of the amino acid distributions within a large zinc finger sequence data base a