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Effect of chloroquine on the bioavailability of ciprofloxacin in man

โœ Scribed by E.C. Ilo; O.E. Orisakwe; N.A. Ilondu; N. Okwoli; S.A. Brown; J. Elo-Ilo; P.U. Agbasi

Book ID
113691413
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
77 KB
Volume
116
Category
Article
ISSN
0168-3659

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โœ Mohsen A. Hedaya; Dalia R. El-Afify; Gamal M. El-Maghraby ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 108 KB

Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4