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Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin

โœ Scribed by Michael B Kays; Brian R Overholser; Bruce A Mueller; Sharon M Moe; Kevin M Sowinski


Book ID
114466431
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
91 KB
Volume
42
Category
Article
ISSN
0272-6386

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Sildenafil is the first oral therapeutic agent for the management of male erectile dysfunction. Its oral bioavailability is only 40% due to extensive presystemic elimination, mainly by CYP3A4. This study examined the effect of coadministration of ciprofloxacin or clarithromycin, which inhibit CYP3A4