Effect of 6-hydroxydopamine on morphine analgesia
โ Scribed by I. H. Ayhan
- Publisher
- Springer
- Year
- 1972
- Tongue
- English
- Weight
- 328 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0033-3158
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After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly p
The analgesic effect of morphine in a mouse writhing assay was enhanced by the simultaneous administration of fluoxetine, an inhibitor of serotonin uptake. Fluoxetine reduced the ED, for morphine and extended the duration of morphine analgesia. The potentiation of morphine analgesia was particularly