Effect of 6-hydroxydopamine
β Scribed by George J. Alexander; Lenore M. Kopeloff
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 228 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0364-3190
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After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly p
In previous studies, we showed that in the monkey, systemically administered N-methyl, 4-phenyl, 1-2-3-6 tetrahydropyridine (MPTP) produces a chronic parkinsonian syndrome accompanied by spatial frequency-dependent abnormalities in both the pattern electroretinogram and visual evoked potential. We d