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The effect of fluoxetine on morphine analgesia, respiratory depression, and lethality

✍ Scribed by Martin D. Hynes; Ray W. Fuller

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
608 KB
Volume
2
Category
Article
ISSN
0272-4391

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✦ Synopsis

The analgesic effect of morphine in a mouse writhing assay was enhanced by the simultaneous administration of fluoxetine, an inhibitor of serotonin uptake. Fluoxetine reduced the ED, for morphine and extended the duration of morphine analgesia. The potentiation of morphine analgesia was particularly striking in mice made tolerant by repeated morphine injections. Potentiation of morphine by fluoxetine was also observed in a rat tail jerk test for analgesia. The acute lethality of morphine in rats and mice was altered by fluoxetine, yet the therapeutic index of morphine (ratio of LD, to ED, , ) was unchanged. The decrease in blood PO, produced by morphine at doses of 1 and 4 mg/kg in rats was attenuated by fluoxetine, which by itself increased blood PO,. These findings strengthen earlier evidence for an involvement of serotoninergic neurons in the analgesic effects of morphine and support the idea that enhanced serotoninergic function might be a useful means of enhancing morphine's actions in clinical therapy.

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