The Wittig reaction between n-butylidenetriphenylphosphorane and a series of cyclohexanones of increasing steric hindrance around the carbonyl group has been studied at 7 kbar and 15 kbar pressure (0.75-1.5 GPa) and at 40 "C.
(E)-Selective Wittig Reactions of Garner′s Aldehyde with Nonstabilized Ylides.
✍ Scribed by Joon Seok Oh; Byung Hyun Kim; Young Gyu Kim
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 89 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
The reaction of aldehydes with oxido ylides shows a dramatic dependence of alkene stereochemistry on the distance between oxygen and phosphorus atoms; ylides with proximal 0 and P atoms favor production of g alkenes. The high r stereoselectivity with r-oxido ylides is not mainly attributable to intr
The Wittig reaction of a pool of stabilised ylides and aromatic aldehydes was carried out in a microwave oven. Only a few minutes were needed for high conversion rates under microwave heating in comparison to hour time with traditional methods.