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Kinetic study of microwave-assisted Wittig reaction of stabilised ylides with aromatic aldehydes

✍ Scribed by Sara Frattini; Monica Quai; Enzo Cereda


Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
57 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


The Wittig reaction of a pool of stabilised ylides and aromatic aldehydes was carried out in a microwave oven. Only a few minutes were needed for high conversion rates under microwave heating in comparison to hour time with traditional methods.


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The reaction of aldehydes with oxido ylides shows a dramatic dependence of alkene stereochemistry on the distance between oxygen and phosphorus atoms; ylides with proximal 0 and P atoms favor production of g alkenes. The high r stereoselectivity with r-oxido ylides is not mainly attributable to intr