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Dual inhibition of neutral endopeptidase and angiotensin converting enzyme delays the progression of experimental heart failure

✍ Scribed by Stevens, Tracy L.; Borgeson, Daniel D.; Redfield, Margaret M.; Luchner, Andreas; Burnett, John C.


Book ID
123343652
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
143 KB
Volume
27
Category
Article
ISSN
1558-3597

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Dual inhibition of angiotensin-convertin
✍ StΓ©phane De Lombaert; Louis Blanchard; Lisa B. Stamford; Yumi Sakane; Carol Berr πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 320 KB

Various thioacyl analogs of CGS 28106, a tricyclic dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase, have been synthesized and their inhibitory potencies evaluated in vitro. The structure-activity relationship supports the proposed hypothesis that, despite its conformational