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CGS 30440: A Dual Inhibitor of Angiotensin-Converting Enzyme and Neutral Endopeptidase 24.11

✍ Scribed by Cohen, David S. ;Fink, Cynthia A. ;Trapani, Angelo J. ;Webb, Randy L. ;Zane, Patricia A. ;Chatelain, Ricardo E.


Book ID
109105971
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
206 KB
Volume
17
Category
Article
ISSN
0897-5957

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ct-Mercaptoaeyl dipoptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition w