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4-Substituted proline derivatives that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11.

โœ Scribed by Shripad S. Bhagwat; Cynthia A. Fink; Candido Gude; Kenneth Chan; Ying Qiao; Yumi Sakane; Carol Berry; Raj D. Ghai


Book ID
108476981
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
271 KB
Volume
4
Category
Article
ISSN
0960-894X

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ฮฑ-Mercaptoacyl dipeptides that inhibit a
โœ Shripad S. Bhagwat; Cynthia A. Fink; Candido Gude; Kenneth Chan; Ying Qiao; Yumi ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 223 KB

ct-Mercaptoaeyl dipoptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition w