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ChemInform Abstract: Design and Synthesis of Phosphinic Acids That Triply Inhibit Endothelin Converting Enzyme, Angiotensin Converting Enzyme and Neutral Endopeptidase 24.11.

โœ Scribed by B. A. MCKITTRICK; A. W. STAMFORD; X. WENG; K. MA; S. CHACKALAMANNIL; M. CZARNIECKI; R. M. CLEVEN; A. B. FAWZI


Book ID
112040210
Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
27
Category
Article
ISSN
0931-7597

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ct-Mercaptoaeyl dipoptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition w