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Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11

✍ Scribed by Brian A. McKittrick; Andrew W. Stamford; Xiaoyu Weng; Ke Ma; Samuel Chackalamannil; Michael Czarniecki; ReneéM. Cleven; Ahmad B. Fawzi

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
304 KB
Volume
6
Category
Article
ISSN
0960-894X

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ct-Mercaptoaeyl dipoptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition w