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In vivo inhibition of angiotensin converting enzyme and neutral endopeptidase by a dual vasopeptidase inhibitor

✍ Scribed by L.M. Burrell; M.D. Rockell; J. Powell; C.I. Johnston


Book ID
117605756
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
146 KB
Volume
12
Category
Article
ISSN
0895-7061

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Dual inhibition of angiotensin-convertin
✍ StΓ©phane De Lombaert; Louis Blanchard; Lisa B. Stamford; Yumi Sakane; Carol Berr πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 320 KB

Various thioacyl analogs of CGS 28106, a tricyclic dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase, have been synthesized and their inhibitory potencies evaluated in vitro. The structure-activity relationship supports the proposed hypothesis that, despite its conformational