Dual inhibition of angiotensin-convertin
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StΓ©phane De Lombaert; Louis Blanchard; Lisa B. Stamford; Yumi Sakane; Carol Berr
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Article
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1996
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Elsevier Science
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English
β 320 KB
Various thioacyl analogs of CGS 28106, a tricyclic dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase, have been synthesized and their inhibitory potencies evaluated in vitro. The structure-activity relationship supports the proposed hypothesis that, despite its conformational