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Mercaptoacyl Dipeptides as Orally Active Dual Inhibitors of Angiotensin-Converting Enzyme and Neutral Endopeptidase

โœ Scribed by Fink, Cynthia A.; Carlson, J. Eric; McTaggart, Patricia A.; Qiao, Ying; Webb, Randy; Chatelain, Ricardo; Jeng, Arco Y.; Trapani, Angelo J.


Book ID
125930540
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
292 KB
Volume
39
Category
Article
ISSN
0022-2623

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ฮฑ-Mercaptoacyl dipeptides that inhibit a
โœ Shripad S. Bhagwat; Cynthia A. Fink; Candido Gude; Kenneth Chan; Ying Qiao; Yumi ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 223 KB

ct-Mercaptoaeyl dipoptides were prepared and found to inhibit angiotensin converting enzyme (ACE) and neutral endopeptidase 24.11 (NEP). Compounds with a proline as the C-terminal amino acid, and possessing the S-stereochemistry at the thiol bearing carbon were preferred for optimal ACE inhibition w