Drug biotransformation interactions in man V: Acetaminophen and salicylic acid
✍ Scribed by Gerhard Levy; Carl-Gunnar Regårdh
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 429 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine, resulting in the formation of hippuric acid and salicyluric acid, respectively. Both processes are capacity-limited in the usual dose range and approach a maximum rate following administration
Computer simulations were used to determine suitable experimental conditions for distinguishing between a recently developed pharmacokinetic model for salicylate elimination (involving saturable salicyl phenolic glucuronide formation) and a previously proposed model (based on the assumption that the