Drug biotransformation interactions in man I. Mutual inhibition in glucuronide formation of salicylic acid and salicylamide in man
β Scribed by Gerhard Levy; Josephine A. Procknal
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 571 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
Computer simulations were used to determine suitable experimental conditions for distinguishing between a recently developed pharmacokinetic model for salicylate elimination (involving saturable salicyl phenolic glucuronide formation) and a previously proposed model (based on the assumption that the
The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine, resulting in the formation of hippuric acid and salicyluric acid, respectively. Both processes are capacity-limited in the usual dose range and approach a maximum rate following administration