Drug biotransformation interactions in man III: Acetaminophen and salicylamide
β Scribed by Gerhard Levy; Hideo Yamada
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 592 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine, resulting in the formation of hippuric acid and salicyluric acid, respectively. Both processes are capacity-limited in the usual dose range and approach a maximum rate following administration
Various high carbohydrate, high protein, and high lipid test meals were administered concurrently with acetaminophen tablets to human subjects to study the effects of foods on GI absorption of this drug. Balanced test meals and a fasting condition were also employed. An indication of the rate and ex