Biotransformation of salicylic acid to its acyl and phenolic glucuronides in man

✍ Scribed by Tamehiro Tsuchiya; Gerhard Levy

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 233 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610530

✦ Synopsis

Computer simulations were used to determine suitable experimental conditions for distinguishing between a recently developed pharmacokinetic model for salicylate elimination (involving saturable salicyl phenolic glucuronide formation) and a previously proposed model (based on the assumption that the syntheses of salicyl phenolic and acyl glucuronides are apparent first-order processes). Experimental studies in man designed on the basis of these simulations yielded results which are in agreement with the new pharmacokinetic model and which represent further evidence that man has a limited capacity to form salicyl phenolic glucuronide.

Key phrases 0 Salicylic acid biotransformation in man-capacitylimited formation of salicyl phenolic glucuronide, compared to computer simulations

Computer simulation of salicylic acid biotransformation-compared to experimental studies in man 0

Biotransformation of salicylic acid-capacity-limited salicyl phenolic glucuronide formation, man