Down-regulation of MHC class I by bovine papillomavirus E5 oncoproteins
β Scribed by Ashrafi, G Hossein; Tsirimonaki, Emmanouella; Marchetti, Barbara; O'Brien, Philippa M; Sibbet, Gary J; Andrew, Linda; Campo, M Saveria
- Book ID
- 110066236
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 525 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex __via__ the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced diβleucine
Malignant transformation is often associated with genetic alterations providing tumor cells with mechanisms for escape from immune surveillance. Human and murine tumors of various origin as well as in vitro models of viral and oncogenic transformation express reduced levels of major histocompatibili