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The bovine papillomavirus oncoprotein E5 retains MHC class I molecules in the Golgi apparatus and prevents their transport to the cell surface

✍ Scribed by Marchetti, Barbara; Ashrafi, G Hossein; Tsirimonaki, Emmanouella; O'Brien, Philippa M; Campo, M Saveria


Book ID
110067032
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
619 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract The E5 oncoprotein of human papillomavirus type 16 downregulates surface MHC Class I and interacts with the heavy chain of the MHC complex __via__ the first hydrophobic domain, believed to form the first helical transmembrane region (TM1) of E5. TM1 contains 4 equally spaced di‐leucine