A major role for tapasin as a stabilizer
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Natalio Garbi; Neeraj Tiwari; Frank Momburg; GΓΌnterβJ. HΓ€mmerling
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Article
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2003
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John Wiley and Sons
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English
β 305 KB
Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In