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Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin

✍ Scribed by A. G. Grandea III; P. J. Lehner; Peter Cresswell; T. Spies


Book ID
105948518
Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
473 KB
Volume
46
Category
Article
ISSN
0093-7711

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A major role for tapasin as a stabilizer
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Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In