Reverse immunogenetic approaches attempt to optimize the selection of candidate epitopes, and thus minimize the experimental effort needed to identify new epitopes. When predicting cytotoxic T cell epitopes, the main focus has been on the highly specific MHC class I binding event. Methods have also
Modeling the MHC class I pathway by combining predictions of proteasomal cleavage,TAP transport and MHC class I binding
✍ Scribed by S. Tenzer; B. Peters; S. Bulik; O. Schoor; C. Lemmel; M. M. Schatz; P.-M. Kloetzel; H.-G. Rammensee; H. Schild; H.-G. Holzhütter
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 386 KB
- Volume
- 62
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In
## Abstract Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for the presentation of CD8^+^ T cells. Three IFN‐γ‐inducible catalytic proteasome (immuno)subunits as well as the IFN‐γ‐inducible proteasome activator PA28 d
## Abstract Murine natural killer (NK) cells are inhibited by target cell MHC class I molecules __via__ Ly49 receptors. However, Ly49 receptors can be made inaccessible to target cell MHC class I by a __cis__ interaction with its MHC class I ligand within the NK cell membrane. It has recently been