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Dopamine Terminal Loss and Onset of Motor Symptoms in MPTP-Treated Monkeys: A Positron Emission Tomography Study with 11C-CFT

✍ Scribed by Ullrich Wüllner; Peyman Pakzaban; Anna-Lisa Brownell; Philippe Hantraye; Lindsay Burns; Timothy Shoup; David Elmaleh; Andrew J. Petto; Roger D. Spealman; Gordon L. Brownell; Ole Isacson


Book ID
115606111
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
288 KB
Volume
126
Category
Article
ISSN
0014-4886

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## Abstract We used [^11^C]raclopride (RACLO) and positron emission tomography (PET) to study longitudinally striatal dopamine D~2~ receptor binding in nine patients with Parkinson's disease (PD) at an early drug‐naive stage and 3–5 years later, when motor fluctuations had appeared in seven of them