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Receptor binding and selectivity of three 11C-labelled dopamine receptor antagonists in the brain of Rhesus monkeys studied with positron emission tomography

✍ Scribed by P. Hartvig; S. Å. Eckernäs; B. Ekblom; L. Lindström; H. Lundqvist; S. Axelsson; K. J. Fasth; P. Gullberg; B. Långström


Book ID
114782688
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
470 KB
Volume
77
Category
Article
ISSN
0001-6314

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By means of positron emission tomography the uptake and kinetics of N-(methyl-11C)clozapine in different brain regions have been studied in Rhesus monkeys. 11C-clozapine rapidly entered the brain and maximum radioactive uptake was seen 5-12 min after administration. Highest uptake was measured in th