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Positron emission tomography quantification of [11C]-(+)-PHNO binding to the dopamine D2/D3 receptors in the human brain

✍ Scribed by Nathalie Ginovart; M. Willeit; P. Rusjan; A. Graff; I. Vitcu; P. Bloomfield; S. Houle; S. Kapur; A. Wilson

Book ID: 118489944
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 56 KB
Volume: 31
Category: Article
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2006.04.020

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## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro