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A combined diffusion tensor imaging (DTI) and [11C]-(+)-PHNO positron emission tomography (PET) study to quantify dopamine D3/D2 receptors in pallidum

✍ Scribed by Andri C. Tziortzi; Gwenaelle Douaud; Paul Shotbolt; Courtney Bishop; Graham Searle; Marc Laruelle; Eugenii A. Rabiner; Mark Jenkinson; Roger N. Gunn

Book ID
119331452
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
141 KB
Volume
52
Category
Article
ISSN
1053-8119

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## Abstract Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain