𝔖 Bobbio Scriptorium
✦   LIBER   ✦

In vivo studies of [125I]iodobenzamide and [11C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D2 dopamine receptors

✍ Scribed by Dean F. Wong; Alan A. Wilson; Catherine Chen; Elynne Minkin; Robert F. Dannals; Hayden T. Ravert; Patricia Sanchez-Roa; Victor Villemagne; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
699 KB
Volume
12
Category
Article
ISSN
0887-4476

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain distribution of radioactivity. Mouse [^125^I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D~2~ receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Long-term changes of striatal dopamine D
Long-term changes of striatal dopamine D2 Receptors in patients with Parkinson's disease: A study with positron emission tomography and [11C]Raclopride
✍ Angelo Antonini; Johannes Schwarz; Wolfgang H. Oertel; Oliver Pogarell; Prof. Kl 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 574 KB

## Abstract We used [^11^C]raclopride (RACLO) and positron emission tomography (PET) to study longitudinally striatal dopamine D~2~ receptor binding in nine patients with Parkinson's disease (PD) at an early drug‐naive stage and 3–5 years later, when motor fluctuations had appeared in seven of them