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Dopamine D2 receptor radiotracers [11C](+)-PHNO and [3H]raclopride are indistinguishably inhibited by D2 agonists and antagonists ex vivo

✍ Scribed by Patrick N. McCormick; Shitij Kapur; Philip Seeman; Alan A. Wilson


Book ID
116799159
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
189 KB
Volume
35
Category
Article
ISSN
0969-8051

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## Abstract The D~2~ receptors exist in either the high‐ or low‐affinity state with respect to agonists, and while agonists bind preferentially to the high‐affinity state, antagonists do not distinguish between the two states. [^11^C]‐(+)‐PHNO is a PET D~2~ __agonist__ radioligand and therefore pro