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Dopamine D1(SCH 23390) and D2(haloperidol) antagonists in drug-naive monkeys

✍ Scribed by Daniel E. Casey

Book ID
105510420
Publisher
Springer
Year
1992
Tongue
English
Weight
509 KB
Volume
107
Category
Article
ISSN
0033-3158

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Blockade of the discriminative stimulus
Blockade of the discriminative stimulus effects of cocaine in rhesus monkeys with the D1dopamine antagonist SCH 23390
✍ Mark S. Kleven; Elizabeth W. Anthony; Leon I. Goldberg; William L. Woolverton πŸ“‚ Article πŸ“… 1988 πŸ› Springer 🌐 English βš– 317 KB

To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted