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Dopamine D1 and D2 receptor agents and their interaction influence the synaptic density of the rat prefrontal cortex

✍ Scribed by Makoto Sugahara; Hiroyasu Shiraishi

Book ID
117477295
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
60 KB
Volume
259
Category
Article
ISSN
0304-3940

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Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit