✦ LIBER ✦

Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat

✍ Scribed by A. John MacLennan; Stella Atmadja; Nancy Lee; H. C. Fibiger

Publisher: Springer
Year: 1988
Tongue: English
Weight: 299 KB
Volume: 95
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00174519

No coin nor oath required. For personal study only.

✦ Synopsis

Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the density of D2 receptors in the striatum by 70% and in the medial prefrontal cortex by 50%. The chronic haloperidol did not significantly alter the apparent affinity of D2 receptors for [3H]-spiperone in either structure. These results indicate that the density of D2 receptors in the medial prefrontal cortex is influenced by chronic exposure to haloperidol in a manner that is very similar to the welt-documented increase that occurs in the striarum.

📜 SIMILAR VOLUMES

Catalepsy after microinjection of halope

Catalepsy after microinjection of haloperidol into the rat medial prefrontal cortex

✍ T. Klockgether; M. Schwarz; L. Turski; K.-H. Sontag 📂 Article 📅 1988 🏛 Springer-Verlag 🌐 English ⚖ 282 KB

To investigate the behavioural role of mesocortical dopamine innervation we performed bilateral microinjections of haloperidol into various parts of the rat frontal cortex and into adjacent subcortical forebrain structures. Haloperidol (2.5 micrograms/0.5 microliter) locally injected into the medial

Local infusion of the serotonin antagoni

Local infusion of the serotonin antagonists ritanserin or ICS 205,930 increases in vivo dopamine release in the rat medial prefrontal cortex

✍ Elizabeth A. Pehek 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 876 KB

Previous research has indicated that atypical antipsychotic drugs like clozapine preferentially increase dopamine (DA) release from the mesocortical, relative to the nigrostriatal, system. While these drugs generally have weak affinity for the D2 receptor subtype, they are potent antagonists of the

Activation of D1 and D2 dopamine recepto

Activation of D1 and D2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex

✍ Rosa M. Izquierdo-Claros; María del Carmen Boyano-Adánez; Eduardo Arilla-Ferreir 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB 👁 1 views

Blockade of D-1 dopamine receptors in th

Blockade of D-1 dopamine receptors in the medial prefrontal cortex produces delayed effects on pre- and postsynaptic indices of dopamine function in the nucleus accumbens

✍ Paul Vezina; Gérard Blanc; Jacques Glowinski; Jean-Pol Tassin 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 998 KB

The present experiments assessed the acute and delayed effects of D-1 dopamine (DA) receptor blockade in the medial prefrontal cortex (mPFC) on pre-and postsynaptic indices of DA neurotransmission in the nucleus accumbens (N.Acc). Different groups of rats received intra-mPFC injections of saline (co

Blockade of tachykinin NK1 receptors att

Blockade of tachykinin NK1 receptors attenuates stress-induced rise of extracellular noradrenaline and dopamine in the rat and gerbil medial prefrontal cortex

✍ Giuliano Renoldi; Roberto W. Invernizzi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 1 views

## Abstract Substance P receptor antagonists cause antidepressant‐ and anxiolytic‐like effects in rodents that are thought to involve brain monoamines. In the present study, we examined the effects of the NK1 receptor antagonist GR‐205,171 on basal and stress‐induced rise of extracellular noradrena

α-noradrenergic receptor modulation of t

α-noradrenergic receptor modulation of the phencyclidine- and Δ9-tetrahydrocannabinol-induced increases in dopamine utilization in rat prefrontal cortex

✍ J. David Jentsch; Alyssa Wise; Zachary Katz; Robert H. Roth 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

The noncompetitive NMDA receptor antagonist phencyclidine (PCP) and the neuronal cannabinoid receptor agonist ⌬ 9 -tetrahydrocannabinol (THC) are two agents shown to have psychotomimetic properties in humans. Both drugs increase dopamine release and utilization in the prefrontal cortex, a brain regi