Dominant lethal test in mice with 6-mercaptopurine
β Scribed by M. Schulze Schencking; H. Frohberg
- Publisher
- Springer-Verlag
- Year
- 1975
- Tongue
- English
- Weight
- 296 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0340-5761
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π SIMILAR VOLUMES
Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p
Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal