𝔖 Bobbio Scriptorium
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Does caffeine induce dominant lethal mutations in mice?

✍ Scribed by Ilse-Dore Adler


Publisher
Springer
Year
1969
Tongue
English
Weight
688 KB
Volume
7
Category
Article
ISSN
0340-6717

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Dominant lethal mutations in male mice
✍ U. H. Ehling πŸ“‚ Article πŸ“… 1977 πŸ› Springer-Verlag 🌐 English βš– 648 KB

Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p

Induction of dominant lethal mutations i
✍ U. H. Ehling πŸ“‚ Article πŸ“… 1978 πŸ› Springer-Verlag 🌐 English βš– 342 KB

Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal