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DNA−DNA Interstrand Cross-Linking by FR66979: Intermediates in the Activation Cascade

✍ Scribed by Paz, Manuel M.; Hopkins, Paul B.

Book ID
127163096
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
266 KB
Volume
119
Category
Article
ISSN
0002-7863

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DNA-DNA interstrand cross-linking by FR6
DNA-DNA interstrand cross-linking by FR66979 and FR900482: Requirement of metal ions during reductive activation
✍ Manuel M. Paz; Paul B. Hopkins 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 315 KB

The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon