𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Covalent Structure of the DNA-DNA Interstrand Cross-Link Formed by Reductively Activated FR66979 in Synthetic DNA Duplexes

✍ Scribed by Huang, Huifang; Pratum, Tom K.; Hopkins, Paul B.


Book ID
127012225
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
761 KB
Volume
116
Category
Article
ISSN
0002-7863

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


DNA-DNA interstrand cross-linking by FR6
✍ Manuel M. Paz; Paul B. Hopkins πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 315 KB

The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon