𝔖 Bobbio Scriptorium
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FR66979 requires reductive activation to cross-link DNA efficiently

✍ Scribed by Huifang Huang; Scott R. Rajski; Robert M. Williams; Paul B. Hopkins


Book ID
103409257
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
493 KB
Volume
35
Category
Article
ISSN
0040-4039

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DNA-DNA interstrand cross-linking by FR6
✍ Manuel M. Paz; Paul B. Hopkins πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 315 KB

The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon