DNA-DNA interstrand cross-linking by FR6
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Manuel M. Paz; Paul B. Hopkins
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Article
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1997
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Elsevier Science
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French
β 315 KB
The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon