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Interstrand Cross-Linking of DNA by FK317 and Its Deacetylated Metabolites FR70496 and FR157471 †

✍ Scribed by Williams, Robert M.; Ducept, Pascal


Book ID
127286071
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
182 KB
Volume
42
Category
Article
ISSN
0006-2960

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The antitumor antibiotics FR66979 and FR900482 are believed to undergo bioreductive activation in vivo, enabling them to alkylate DNA. Reduction has previously been accomplished in vitro using sodium dithionite or dithiothreitol. We find that metal ions are a previously unrecognized, critical compon